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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL3
All Species:
23.94
Human Site:
S276
Identified Species:
40.51
UniProt:
Q8IVW4
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVW4
NP_001107047.1
592
67514
S276
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
Chimpanzee
Pan troglodytes
XP_517934
592
67566
S276
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
Rhesus Macaque
Macaca mulatta
XP_001108660
592
67612
S276
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
Dog
Lupus familis
XP_850612
456
51739
M190
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLF2
595
67720
S276
I
D
P
A
E
R
T
S
S
T
D
L
L
R
H
Rat
Rattus norvegicus
Q9JM01
593
67534
S276
I
D
P
A
E
R
I
S
S
T
D
L
L
H
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
S276
I
D
P
E
D
R
I
S
S
T
A
L
L
H
H
Chicken
Gallus gallus
P13863
303
34670
L37
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
Frog
Xenopus laevis
P35567
302
34487
R36
V
V
A
M
K
K
I
R
L
E
N
E
E
E
G
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
D84
H
L
V
F
E
Y
C
D
H
T
V
L
N
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
A31
R
L
T
G
Q
I
V
A
M
K
K
I
R
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
T277
L
D
P
D
Q
R
P
T
C
T
Q
F
L
K
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
E28
A
L
D
K
A
T
N
E
T
I
A
L
K
K
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
E28
A
R
D
K
V
T
N
E
T
I
A
L
K
K
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
67.7
N.A.
80.5
79
N.A.
57.7
25
24.3
31
N.A.
23.4
N.A.
N.A.
30.2
Protein Similarity:
100
99.8
99.6
72.1
N.A.
89.7
87.6
N.A.
68.9
34.9
35.6
43
N.A.
35.1
N.A.
N.A.
44
P-Site Identity:
100
100
100
6.6
N.A.
73.3
86.6
N.A.
80
6.6
6.6
6.6
N.A.
0
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
20
N.A.
86.6
100
N.A.
86.6
20
26.6
20
N.A.
20
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
22.8
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
33.9
N.A.
33.9
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
8
43
8
0
0
8
0
0
22
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
15
0
8
0
0
0
0
0
0
% C
% Asp:
8
50
15
8
29
0
0
8
0
0
36
0
0
0
0
% D
% Glu:
0
0
0
8
22
0
0
15
8
8
15
15
15
15
8
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
0
0
0
8
15
% G
% His:
8
0
0
0
0
0
0
0
8
0
0
0
0
36
50
% H
% Ile:
43
8
0
0
0
15
43
0
8
22
0
8
0
0
15
% I
% Lys:
0
0
0
22
15
8
0
0
0
8
8
0
15
22
0
% K
% Leu:
8
22
0
0
8
0
0
8
8
0
0
65
50
8
8
% L
% Met:
0
0
8
8
0
0
0
8
8
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
15
0
0
0
8
0
8
0
0
% N
% Pro:
0
0
50
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
15
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
8
8
0
0
0
50
8
8
0
0
0
0
8
8
0
% R
% Ser:
0
0
0
0
0
0
0
43
43
29
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
15
8
8
15
36
0
0
0
8
0
% T
% Val:
15
8
8
0
8
0
8
0
0
0
8
0
0
0
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _